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KMID : 1149220200280020189
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Korean Journal of Oriental Medical Prescription
2020 Volume.28 No. 2 p.189 ~ p.198
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Herbal formula MJY2018 protects against Alcohol-induced liver injury mice model
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Kim Kwang-Youn
Park Kwang-Il
Cho Won-Kyung
Yang Ju-Hye
Ma Jin-Yeul
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Abstract
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Objectives : This study investigated the liver-protective effects of MJY2018, a Herbal formula, against alcoholic fatty liver disease and anti-oxidative effects.
Methods : Its effects were investigated in an alcoholic fatty liver disease model in male C57BL/6 mice, which were fed Lieber?DeCarli liquid diet containing ethanol. MJY2018 (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days.
Results : The results indicate that MJY2018 promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, MJY2018 reduced accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the livers of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity.
Conclusions : These results indicate that MJY2018 were effective in improving and protecting oxidative stress and alcoholic liver disease.
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KEYWORD
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herbal formula, MJY2018, alcohol, liver damage, antioxidant
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